Paediatric anti-GABAB receptor encephalitis associated with SARS-CoV-2 (COVID-19) infection

Though we are approaching the end of second wave COVID pandemic, still unrevealing various presentation this viral infection can result in. There few cases reported to have anti NMDA autoimmune encephalitis associated with COVID-19 or MIS-C. Here reporting one its variants that was anti-GABAB receptor infection. We a 9 years old female child who known case seizure disorder and on regular medications presented 4th day RT-PCR positive status for complains convulsions which managed antiepileptics. On 6 hospitalization she had autonomic instability in form tachyarrhythmia, repitation speech, sudden outburst laughter 7 landed epilepticus. Autoimmune suspected secondary started IVIG but not much improvement seen this. CSF analysis showed weakly GABAB antibodies persistently elevated inflammatory markers hence high dose corticosteroid. MIS-C ruled out. Child drastic both clinical biochemical after corticosteroids. Prompt treatment IVIG/corticosteroids shown our just like any other encephalitis. further detailed study is required prove exact mechanism infection, it should be thought when appropriate prompt early initiation therapy will help us reduce morbidity mortality it.